Microfluidic biochip-2

Microfluidic biochip for the perifusion of precision-cut rat liver slices for metabolism and toxicology studies

FREE DOWNLOAD [PDF]PM van Midwoud, GMM Groothuis… – Biotechnology and …, 2010

ABSTRACT: Early detection of kinetic, metabolic, and toxi- city (ADME-Tox) profiles for new drug
candidates is of crucial importance during drug development. This article describes a novel in
vitro system for the incubation of precision-cut liver slices (PCLS) under flow conditions,