Clinical chemistry




A multi-rule Shewhart chart for quality control in clinical chemistry
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A statistical control procedure is an important element in a total system of quality control. The purpose of this discussion is to outline a simple statistical procedure that is widely applicable and practical in clinical laboratories. The control procedure recommended here is for

International Federation Of Clinical Chemistry
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1) The exclusive 0 for all languages and countries is vested in The International Federation of Clinical Chemistry . 2) IFCC Sections reprinted in J. Clin. Chem. Clin. Biochem. are listed in the Cumulative Index, which appeared in connection with the contents of this journal

equality of measurements from two different analytical methods. Application of linear regression procedures for method comparison studies in clinical chemistry
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Procedures for the statistical evaluation of method comparisons and Instrument tests often have a requirement for distributional properties of the experimental data, but this requirement is frequently not met. In our paper we propose a new linear regression

Haemolysis äs an interference factor in clinical chemistry
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Using fully mechanized analytical equipment, interference by haemolysis in the determination of 26 clinical chemical parameters was determined quantitatively by adding haemolysate to serum. Haemoglobin concentrations up to 6.6 g/l caused essentially no

A general regression procedure for method transformation. Application of linear regression procedures for method comparison studies in clinical chemistry Part
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The bioinetrical treatment of laboratory data require the estimation of a regression line for the transformation of one set of measurements to another. The regression procedure introduced in part I (1) of our work does not always yield unbiased results in such situations

A multivariate approach for the biometrie comparison of analytical methods in clinical chemistry
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The structural relationship model is recommended for the comparison of analytical methods in clinical chemistry . This model is based on the partition of the observed measurements of the different methods in 2 hypothetical random variables: the expected values, which

method comparison studies and determination of sample sizes application of linear regression procedures for method comparison studies in clinical chemistry
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In part I of this series (H. Passing W. Bablok (1983), J. Clin. Chem. Clin. Biochem. 2 709 720) we described a new biometrical procedure for the evaluation of method comparison studies. In part II we now discuss its properties and compare them with th se of other

Interpretation of clinical chemistry laboratory data
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The results of clinical laboratory tests performed on individuals often change with time. These changes could well be related to disease states, or changes brought about by treatment of diseases. Such changes can be used to follow the efficacy of the treatment or

Determination of creatinine in human serum by isotope dilution-mass spectrometry. Definitive methods in clinical chemistry IV
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Biochem. Vol. 23. 198 pp. 137-144 Determination of Creatinine in Human Serum by Isotope Dilution-Mass Spectrometry : Definitive Methods in Clinical Chemistry IV i \ By L. Siekmann i Institut für Klinische Biochemie, Universität Bonn lj l (Received September 12/October 2 1984)

Enzyme thermistor analysis in clinical chemistry and biotechnology
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The combination of calorimetry and immobilized enzymes forms a pair with unique properties. Calorimetry is a general detection principle and specificity is introduced by the enzyme. We discuss here simple semi-adiabaticcalorimeters and their application in

Reference materials and reference methods in clinical chemistry
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In clinical chemistry today there are often several different methods and instruments in use for the analysis of a particular constituent. When these different methods and instruments are used for careful analysis of the same control specimen, as in assigned value determinations

Determination of cortisol in human plasma by isotope dilution-mass spectrometry. Definitive methods in clinical chemistry I
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883 J. Clin. Chem. Clin. Biochem. Vol. 198 pp. 883-892 Determination of Cortisol in Human Plasma by Isotope Dilution-Mass Spectrometry Definitive Methods in Clinical Chemistry l By£. Siekmann and/f. Breuer f !) Institut für Klinische Biochemie, Universität Bonn (Received March

Determination of oestradiol-17ß in human serum by isotope dilution-mass spectrometry. Definitive methods in clinical chemistry II
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Isotope Dilution-Mass Spectrometry Definitive Methods in Clinical Chemistry II By L. Siekmann Introduction At present, methods for the determination of steroid hormones in human serum are based almost entirely on the principle of enzyme or radioimmunoassay. These methods are

Determination of uric acid in human serum by isotope dilution-mass spectrometry. Definitive methods in clinical chemistry III
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129-135 Determination of Uric Acid in Human Serum by Isotope Dilution-Mass Spectrometry Definitive Methods in Clinical Chemistry III By L. Siekmann Institut für Klinische Biochemie, Universität Bonn The accuracy of the method is obtained by the use of the highly specific techniqueExtensive data demonstrates that the quality impact of automation is often disappointing, and be no better than manual operations in many cases. When automated equipment is not set up or operated properly, large quantities of non-conformances are generated, which

Tietz textbook of clinical chemistry and molecular diagnostics
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Learning outcomes: At the end of the lectures, students should be able to: 1. List commonly used equipment in Biochemistry laboratory 2. Explain the principle (s) of commonly used equipment in Biochemistry laboratory 3. Select (and justify the choice) appropriate

Quantities and units in clinical chemistry : Nebulizer and flame properties in flame emission and absorption spectrometry (Recommendations 1986)
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A c1assifcation of quantitative concepts, a unification of nomenclature, and suggestions for the introduction and implementation of recommended units for quantities relating to the nebulizer and flame components of emission and absorption spectrometers are presented

Rationale for reference methods in clinical chemistry
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In the field of clinical chemistry evidence is mounting that a reliable and medically relevant structure can be built on the concept of compatibility through accuracy in measurement. By compatibility is meant the ability of all laboratories in a network to achieve on a given sample