Precision medicine and big data




Precision medicine is a medical model that proposes the customization of healthcare, with medical decisions, treatments, practices, or products being tailored to a subgroup of patients, instead of a one‐drug‐fits‐all model.

Using the genetic changes in a patient’s tumor to determine their treatment is known as precision medicine. Precision medicine is an approach to patient care that allows doctors to select treatments that are most likely to help patients based on a genetic understanding of their disease.

Genomic big data and privacy: challenges and opportunities for precision medicine
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Genome science is rapidly shifting from research labs and biobanks to the clinical setting. The resulting genomic big data or large-scale networked genetic material, is a disruptive technology. On one hand, clinical genomics advances life-saving innovation throughThere is potential value in incorporating biomedical big data (BBD) observational real- world patient-level genomic and clinical data in multiple sub-populations into economic evaluations of precision medicine . However, health economists face practical and Purpose of review To survey the literature around big data and artificial intelligence use, its challenges, and examples in clinical and research domains within neurocritical care. Recent findings Innovations in digital data storage and integration technology have

Big Data and the Evolution of Precision Medicine
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Page 1. Big Data and the Evolution of Precision Medicine Dr. George Poste Chief Scientist, Complex Adaptive Systems Initiative and Del E. Webb Chair in Health Innovation Arizona State University george.poste@asu.edu www.casi.asu.edu Michigan Institute for Data Science (MIDAS)

Gateways to Science: Harnessing Big Data and Open Data for Precision Medicine
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The importance of Big Data and Open Data to achieve scientific advancements in precision medicine is beyond doubt and evident in many different projects and initiatives such as the Precision Medicine Initiative (All of Us), ICTBioMed, NCIP Hub, 100K Genomics England

Cloud-computing and precision medicine : Big data offers big opportunities
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Research on large shared medical datasets and datadriven research are gaining fast momentum and provide major opportunities for improving health systems as well as individual care. Such Open Data can shed light on the causes of disease and effects of

Big Data and Precision Medicine
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This paper focuses on clinical data taken from diversified sources that can be utilized to predict medical conditions. Precision medicine being top priority in medication is main essence to describe treatment based on individual physiology, genetic makeup and other

Biomedical Big Data and Precision Medicine
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It includes 10 421 adult inpatients (16 466 index admissions) discharged from March 2011 to July 3 2012. There are 298 independent variables, including:(1) administration variables: age, gender, race, quarter of index admission, insurance, medical service group

BIOINFORMATICS APPROACHES FOR BIG DATA ANALYTICS IN PRECISION MEDICINE : AN OVERVIEW
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Personalized medicine promises for quality treatment and better recovery of patients in near future. The success of personalized medicine can be attributed to the technology advancement that enable us to deal with big data . In spite of enormous amount of biological

The Future of Tuberculosis Control using Precision Medicine Technology and Big Data Concepts
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Mycobacterium Tuberculosis, TB, is one of the deadliest diseases in the world, it causes over 1.3 million deaths per year. There has been constant need for innovative research methods on a clinical basis to combat the spread of TB and ultimately lead to the eradication

Precision Medicine
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On January 201 US President Obama announced at his 2015 State of the Union Address that he was launching a new precision medicine initiative . On January the Obama administration unveiled details about the Precision Medicine Initiative. Launched

Genomic big data and privacy: challenges and opportunities for precision medicine
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Genome science is rapidly shifting from research labs and biobanks to the clinical setting. The resulting genomic big data or large-scale networked genetic material, is a disruptive technology. On one hand, clinical genomics advances life-saving innovation throughThere is potential value in incorporating biomedical big data (BBD) observational real- world patient-level genomic and clinical data in multiple sub-populations into economic evaluations of precision medicine . However, health economists face practical and

Big data analytics to improve cardiovascular care: promise and challenges
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eight areas of application of big data analytics to improve cardiovascular care, including predictive modelling for risk and resource use, population management, drug and medical device safety surveillance, disease and treatment heterogeneity, precision medicine and clinical

Precision medicine in cardiology
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Box 1 | Major medical advances enabling precision medicine Completion of the Human Genome Project1 15 Launch of the International new techniques in computational biology were developed, making the handling of large datasets possible ( big data )22 Widespread Page 3. Christoph Thuemmler Chunxue Bai Editors Health 4.0: How Virtualization and Big Data are Revolutionizing Healthcare 123 Page 4 Personalized medicine or precision medicine will allow for individualized treatment anywhere, anyhow and at any time

Fairness in precision medicine
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individuals in relation to others, about groups of people, or simply about the structure of information itself. 14 Precision medicine research specif- ically hinges on the ability of big data analysis to reveal relationships that can provide insights on the myriad causes of diseaseas machine learning, deep learning, and natural language processing (NLP) to tackle the challenges of scalability and high dimensionality of data and to transform big data into clinically actionable knowledge is expanding and becoming the foundation of precision medicine

Digital futures past-The long arc of big data in medicine
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Big data be the future of medicine but it is also its past. In 196 the inventor Vladimir Zworykin warned that medical data were accu- mulating at a pace diagnoses, store medical records, and circulate information.2 Though todays world of precision medicine neural nets Purpose of review To survey the literature around big data and artificial intelligence use, its challenges, and examples in clinical and research domains within neurocritical care. Recent findings Innovations in digital data storage and integration technology haveWe critically evaluate big data challenges in precision medicine Table 1 Big data challenges in precision medicine and cancer systems biology Big data characteristic Definition Big data challenges in precision medicine and cancer systems biology

Towards precision medicine
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In this Review, I describe promising applications of precision medicine as it currently exists then move on to discuss the challenges our community needs to face, in the areas of sequencing technology, algorithm development and data sharing, to bring genomics up to clinical

Radiation oncology in the era of precision medicine
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of the therapeutic window of radiation oncology in the era of precision medicine : technology-driven 15Department of Radiation Oncology, Faculty of Medicine and University Hospital Tübingen, Eberhard Karls research in this field and approaches to include these data in radi

Health data cooperatives-citizen empowerment
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3. The Citizen The Third Pillar in Precision Medicine and Personalized Health a) the core for data ac- quisition and secure data management, b) the app store to provide meaningful applications and visualizations for citizens of their data and c) the Big Data ana- lytics

Functional precision cancer medicine moving beyond pure genomics
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Although some call the entire project of precision cancer medicine into question, I suggest instead that the tools employed must be broadened. Instead of relying exclusively on big data measurements of initial conditions, we should also acquire highly actionable functional

The precision medicine initiative cohort program Building a Research Foundation for 21st Century Medicine
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Building the cohort Strategies to address community engagement and health disparities ▪ FNIH Survey of public perceptions of precision medicine cohort Enable targeted clinical trials of subjects with rich clinical data ▪ Make big data broadly available to investigators 10 the Precision Medicine Initiative, which aims to accelerate progress toward precision med- icine (http://www.whitehouse.gov/ precisionmedicine ). Precision medicine needs to bring more sophisticated algorithms, such as deep learning for heterogeneous big data to current data

4 BIG QUESTIONS
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Can academia create better career tracks for bioinformaticians How can knowledge from big data be brought into point- of-care health-care delivery Delivering precision medicine will immensely broaden the scope of electronic health records

Emerging applications of metabolomics in drug discovery and precision medicine
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The goal of precision medicine is to use advanced diagnostic testing to customize an indivi duals medical treatment according to their specific omic profiles Emerging applications of metabolomics in drug discovery and precision medicine David S. Wishart1 3

Big Data science and its applications in health and medical research: Challenges and opportunities
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Journal of Biometrics Biostatistics ISSN: 2155-6180 Jo u rn al o f Biometrics Bios ta tis tics Keywords: Big data science; Big Data infrastructure; Advanced analytics; Human genomics; Precision medicine The Big Data Impact and Potentials in Health and Medical Sciences