Chloroquine treatment to malaria


Chloroquine is a medication primarily used to prevent and treat malaria in areas where malaria remains sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication.

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Impact of chloroquine resistance on malaria mortality
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Over 12 years, from 1984 to 199 we conducted a prospective study of overall and malaria specific mortality among three rural populations in the Sahel, savanna and forest areas of Senegal. The emergence of chloroquine resistance has been associated with a dramatic MALARIA parasites 1 or mammalian liver 2 suitably exposed to chloroquine rapidly form autophagic vacuoles; in the case of the parasites, these are visible under the light microscope because they contain clumps of pigment, the remains of haemoglobin digestion

Chloroquine -resistant Plasmodium vivax
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P mvax)+= sparse trophozoites.* Serum chloroquine levels in this attack were measured on days 2 ( 14), 1 and 15 and were 23 21 28 6 5 and 33 ng/ml, respectively. Smear was negative on day 3 (no smears done on other days). later with IN a previous communication 1 it was reported, that the antimalarial drug, chloroquine , becomes highly concentrated in red blood cells containing the malarial parasite, Plasmodium berghei, through a mechanism of uptake which appears qualitatively distinct

Adding chloroquine to conventional treatment for glioblastoma multiforme: a randomized, double-blind, placebo-controlled trial
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Background: Malignant cell clones resistant to chemotherapy and radiotherapy frequently lead to treatment failure in patients with glioblastoma multiforme. Preliminary studies suggest that adding chloroquine to conventional therapy improve treatment outcomes THE lethal form of human malaria caused by Plasmodium falciparum is virtually uncontrollable in many areas because of the development of drug resistance, in particular chloroquine resistance (CQR). CQR is biologically similar to the multiple drug resistance

Recommendations on screening for chloroquine and hydroxychloroquine retinopathy: a report by the American Academy of Ophthalmology
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Retinal toxicity from chloroquine and its analogue, hydroxychloroquine, has been recognized for many years. The first reports concerned long-term usage of chloroquine for malaria, and later reports showed retinopathy in the treatment of anti-inflammatory diseases

An integrated model of chloroquine action
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Conclusion The field of transport and trafficking in the malaria-infected erythrocyte has been spurred on by the application of modern biochemical, physiological and genetic methods, and by the data now emerging from the Malaria Genome Project. Within the next few years RESISTANCE of malarial parasites to Chloroquine and its analogues was first reported in 1961 and during the past several years has caused increasing concern. Among the possible mechanisms to be considered in the development of drug resistance is production

Chloroquine for the 2019 novel coronavirus
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Page 1. Journal Pre-proof Chloroquine for the 2019 novel coronavirus ANTAGE 105923 To appear in: International Journal

Chloroquine and hydroxychloroquine as available weapons to fight COVID-19
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Page 1. Journal Pre-proof Chloroquine and hydroxychloroquine as available weapons to fight COVID-19 THIS communication describes an investigation of the effects of chloroquine treatment on the ultrastructure of Plasmodium berghei in the mouse and rat, and of P. cynomolgi in the rhesus monkey. Chloroquine was given to the animals intraperitoneally in doses which

A molecular marker for chloroquine -resistant falciparum malaria
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areas raises the specter of delayed oncogenesis in neighboring soft tissue and has been implicated in the constriction of vessels at the margins of irradiated stents the so-called candy wrapper or

Effect of chloroquine on the internalization of 125I-insulin into subcellular fractions of rat liver. Evidence for an effect of chloroquine on Golgi elements.
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MATERIALS AND METHODS Animab-Female and male Sprague-Dawley rats were obtained from Canadian Breeding Laboratories and maintained on Purina Chow for several days before study. The animals weighed 165-225 g at the time of use and were fasted

Chloroquine -quinacrine association in resistant cutaneous lupus
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From March 1993 to June 199 15 patients with histologically confirmed refractory cutaneous lupus lesions were included in this study (table 1). There were 14 women and 1 man. The mean age was 39.5 years (range 25-58). Eight patients did not fulfill ARA criteria

Inhibition of lysosomal phospholipase A and phospholipase C by chloroquine and 4-bis (diethylaminoethoxy) alpha, beta-diethyldiphenylethane.
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The administration of 4-bis (~ e~ yl~ noethoxy)-e,@ liethyldiphenylethane to mau or animals causes phospho~ pid storage in liver, spleen, and other body tissues. Chloroquine has also been shown to cause phospho~ pid storage in animal tissues. In a previous study

Chloroquine accumulation in isolated rat liver lysosomes
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Since hydrolytic processes in lysosomes are catalysed by hydrolases with an acid pH optimum, the intralysosomal pH must be low enough to allow the enzymes to function efficiently [l]. Indeed, qualitative observations on lysosomes in vivo [2-61 indicate that the

Chloroquine inhibits tumor necrosis factor production by human macrophages in vitro
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Colleagues-Much has been published about production oftumor necrosis factor (TNF) by human macrophages. It is thought that blood sampling for TNF must be done with great care using a pyrogene-free anticoagulant and blood-collecting system. Then plasma or serum Nomenclature is important, but confusing. Although the book focuses on chloroquine and hydroxychloroquine, much of it applies to other related drugs (eg, quinacrine). These drugs were formerly termed antimalarials, as they were first used against malaria. However, their

Protective role of tetrahydrocurcumin (THC) an active principle of turmeric on chloroquine induced hepatotoxicity in rats
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PURPOSE. Tetrahydrocurcumin (THC) is an antioxidative substance, which is derived from curcumin, the component of turmeric. In the present investigation, the effect of THC and curcumin against chloroquine (CQ) induced hepatotoxicity were studied in female Wistar