clinical management


Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona-2000 EASL conference
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Hepatocellular carcinoma (HCC) is a neoplasm the incidence of which is increasing worldwide, but striking geographical differences are observed for both risk factors and occurrence . HCC represents more than 5% of all cancers and the estimated annual

Clinical managementimipramine/placebo administration manual
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The Clinical Management Imipramine/Placebo Administration Manual was written in response to a request from the NIMH Treatment of Depression Collaborative Research brogram to develop a standard procedure for the administration of the imipramine and

The clinical management of snake bites in the Southeast Asian region
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Page 1. WHO/SEARO GUIDELINES FOR THE CLINICAL MANAGEMENT OF SNAKE BITES IN THE SOUTHEAST ASIAN REGION Written and edited by David A Warrell with contributions by an international panel of experts World Health Organization Regional Office for South-East Since the first edition of this book appeared in 198 assistance for memory-impaired people has improved a little. The Amnesia Association was founded in 1986 and a number of local Amnass groups meet regularly throughout the United Kingdom. Although help is still hard toPurpose To review the pathophysiology of coagulopathy in massively transfused, adult and previously hemostatically competent patients in both elective surgical and trauma settings, and to recommend the most appropriate treatment strategies. Methods Medline was

Clinical management of breast cancer heterogeneity
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Traditionally, intertumour heterogeneity in breast cancer has been documented in terms of different histological subtypes, treatment sensitivity profiles, and clinical outcomes among different patients. Results of high-throughput molecular profiling studies have subsequently

Hyperglycemia in acute ischemic stroke: pathophysiology and clinical management
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Patients with acute ischemic stroke frequently test positive for hyperglycemia, which is associated with a poor clinical outcome. This association between poor glycemic control and an unfavorable prognosis is particularly evident in patients with persistent hyperglycemia

Clinical management factors contribute to the decision for contralateral prophylactic mastectomy
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Tari A. King, Rita Sakr, Sujata Patil, Inga Gurevich, Michelle Stempel, Michelle Sampson, and Monica Morrow See accompanying editorial on page 2132 From Memorial Sloan-Kettering Cancer Center, New York, NY. Submitted March 1 2010; accepted November 2010; published online

Epidermal growth factor receptor inhibitor associated cutaneous toxicities: an evolving paradigm in clinical management
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Epidermal growth factor receptor inhibitors (EGFRIs) have demonstrated improved overall survival in patients with non-small cell lung cancer, pancreatic cancer, and colorectal cancer; however, their use is associated with dermatologic reactions of varying severity. The

Indications for imatinib mesylate therapy and clinical management
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ABSTRACT Imatinib mesylate (Gleevec, Glivec, formerly STI571; Novartis Pharma AG; Basel, Switzerland) is a rationally-designed, molecularly-specific oral anticancer agent that selectively inhibits several protein tyrosine kinases central to the pathogenesis of human

Endometriosis: epidemiology, diagnosis and clinical management
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Abstract Purpose of Review Endometriosis is a disease of adolescents and reproductive- aged women characterized by the presence of endometrial tissue outside the uterine cavity and commonly associated with chronic pelvic pain and infertility. Here we review the

The clinical management of rheumatoid arthritis and osteoarthritis: strategies for improving clinical effectiveness.
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I, clinical practice is evidence based and patient related expenditure (Table II) . Despite this expenditure, a recent large survey of people with arthritis centred. Routine practice in the UK has tended to evolve in a piecemeal fashion in response to local showsthattheycontinuetohaveconsiderable Opinion statement Chondrosarcomas (CHS) represent a heterogeneous group of disorders ranging from indolent, low-grade tumors to aggressive, high-grade forms. Surgical resection represents the primary and preferred treatment modality for individuals with localized

Clinical management of severe acute respiratory infection when novel coronavirus (‎‎‎ nCoV)‎‎‎ infection is suspected: interim guidance, 25 January 2020
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This is the first edition of this document for novel coronavirus, an adaption of WHO Clinical management of severe acute respiratory infection when MERS-CoV infection is suspected publication (2019). This document is intended for clinicians taking care of hospitalised adult

Clinical management of severe acute respiratory infection (SARI) when COVID-19 disease is suspected: interim guidance, 13 March 2020
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1. Background Coronavirus disease 2019 (COVID-19) is a respiratory tract infection caused by a newly emergent coronavirus, SARS-CoV- that was first recognized in Wuhan, China, in December 2019. Genetic sequencing of the virus suggests that SARS-CoV-2 is a

Scientific understanding and clinical management of Dupuytren disease
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Dupuytren disease (DD) is a fibroproliferative disorder of unknown etiology that often results in shortening and thickening of the pal fascia, leading to permanent and irreversible flexion contracture of the digits. This Review provides a detailed update of the scientific

Clinical management of chronic Chagas cardiomyopathy
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Chagas disease is caused by a protozoan parasite, Trypanosoma cruzi, and infects over 15 million people worldwide. New cases of the disease are now uncommon, mainly due to national control programs in Latin America. However, there is a large reservoir of chronically infected

Li-Fraumeni syndrome: cancer risk assessment and clinical management
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Carriers of germline mutations in the TP53 gene, encoding the cell-cycle regulator and tumour suppressor p5 have a markedly increased risk of cancer-related morbidity and mortality during both childhood and adulthood, and thus require appropriate and effective

Gene discovery in amyotrophic lateral sclerosis: implications for clinical management
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Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease predominantly affecting upper and lower motor neurons. The disease leads to relentlessly progressive weakness of voluntary muscles, with death typically resulting from diaphragmatic failure within 2 5 years

Luminal B breast cancer: molecular characterization, clinical management and future perspectives
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Gene expression profiling has reshaped our understanding of breast cancer by defining and characterizing four main intrinsic molecular subtypes: human epidermal growth factor receptor 2 enriched, basal-like, luminal A, and luminal B subtypes. Luminal B breast cancer