Precision medicine for




Precision medicine for metastatic breast cancer limitations and solutions
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The development of precision medicine for the management of metastatic breast cancer is an appealing concept; however, major scientific and logistical challenges hinder its implementation in the clinic. The identification of driver mutational events remains the

Precision medicine for urothelial bladder cancer: update on tumour genomics and immunotherapy
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Effective management of advanced urothelial bladder cancer is challenging. New discoveries that improve our understanding of molecular bladder cancer subtypes have revealed numerous potentially targetable genomic alterations and demonstrated the efficacy

Precision medicine for individual patients should use population group averages and larger, not smaller, groups
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Advocates of precision medicine propose that individual patients require evidence tailored to their singular, unique and personal profile. According to this way of thinking, population‐ based research, randomized clinical trials (RCTs) and evidence‐based medicine (EBM) are

Drug development in the era of precision medicine
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Page 1. Since the beginning of the human genome project, there has been exceptional enthusiasm for how genetics and eventually genomics would transform drug discovery. With the benefit of hindsight, it is now clear that much of this enthusiasm was, at best, premature

Functional precision cancer medicine moving beyond pure genomics
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the data. JAMA Oncol. 717 718 (2016). 7. Swanton, C. et al. Consensus on precision medicine for metastatic cancers: a report from the MAP conference. Ann. Oncol. 2 1443 1448 (2016). 8. Druker, BJ et al. Efficacy and

Precision oncology: an overview
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Society of Clinical Oncology. All rights reserved. Page 3. 9. Roychowdhury S, Chinnaiyan AM: Advanc- ing precision medicine for prostate cancer through genomics. J Clin Oncol 31:1866-187 2013 10. Dienstmann R, Rodon JPage 1. Intensive Care Med (2017) 43:1507 1509 DOI 10.1007/s00134-017-4727- y EDITORIAL Intensive care medicine in 2050: precision medicine Hector R.

Precision medicine for managing chronic diseases
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Precision medicine (PM)-an important modern paradigm for combining new types of metrics with big datasets-creates predictions for prevention, diagnosis, and specific therapies in chronic diseases. The aim of this paper is to differentiate PM from personalized medicine, to

Sensitive and specific detection of circulating tumor cells promotes precision medicine for cancer
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Circulating tumor cells (CTCs) have the potential to provide genetic information for heterogeneous tumors, which be useful for monitoring disease progression and developing personalized therapies. However, the isolation of CTCs for molecular analysis is

Fairness in precision medicine
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Page 1. Fairness in Precision Medicine Kadija Ferryman Mikaela Pitcan February 2018 Page 2. FAIRNESS IN PRECISION MEDICINE Data SocietyPage 1. REVIEW Precision medicine review: rare driver mutations and their biophysical classification Ruth Nussi 2 Hyunbum Jang1 Chung-Jung Tsai1 Feixiong Cheng 5 Received: 4 December 2018 /Accepted Ovarian clear cell carcinoma (OCCC) is a histological subtype of epithelial ovarian carcinoma prevalent in Asians. No clear therapeutic selection based on molecular profile has been implemented for this disease. Oncogenic PIK3CA mutation, which activates the Page 1. Vol.:(0123456789) 1 3 International Journal of Clinical Oncology (2019) 24:131 140 https://doi.org/10.1007/s10147-018-1373-5 REVIEW ARTICLE Clinical target sequencing for precision medicine of breast cancer

On the brink of precision medicine for psychosis: treating the patient, not the disease: a commentary on: association between serum levels of glutamate and
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With major scientific developments, precision medicine for psychiatry holds the promise for psychosis prevention and accurate prediction of individual treatment response, bringing hope for much needed effective and safe customized treatments. Although, biologically

Non-invasive metabolic imaging of brain tumours in the era of precision medicine
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Precision medicine for brain tumours The subclassification of brain tumours into distinct groups that can inform the clinical management of patients, beyond what is possible based on analyses of histological grade alone, is another important develop- ment arising from

Internet of Medical Imaging Things and Analytics in Support of Precision Medicine for the Case Study of Thyroid Cancer Early Diagnostics
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In this paper the role of advanced IT technologies such as Internet of medical imaging Things and analytics in support and promotion of precision medicine has been revealed considering the case study of early thyroid cancer diagnostics. The concept of precision

Turning Point towards Blood Biomarker-Guided Targeted Therapy for Precision Medicine in Alzheimers Disease
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The standardization of a comprehensive matrix of blood- based AD biomarkers will represent a milestone in the implementation of precision medicine for treating and preventing AD and other neurodegenerative diseases (ND)He adds that precision medicine for mental disorders will not come from a single genomic glitch BMJ, 34 g1687. doi:10.1136/bmj.g1687. Insel, T. (2015). Directors Blog: Precision medicine for mental disorders. Retrieved January 201 from http://www.nimh.nih

Precision Medicine for Aortic Stenosis: The Future of Cardiology Today
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Despite all our success in cardiology, we are still, in some ways, working at an obtuse level. We try and find individual markers for disease pathology (1), risk (2), or for triaging patients for certain therapies (3), and when that is not possible, we create small multivariable

Advancing precision medicine for the treatment of long-QT syndrome type 2: shedding light on lumacaftor
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Congenital long-QT syndrome (cLQTS) typically prolongs the QT interval on an electrocardiogram (ECG) to increase the risk for ven- tricular arrhythmias including the potentially fatal tachyarrhythmia Torsades de Pointes (Take home figure A). 2 The autosomal dominant form of cLQTS (originally

Sensitive and specific detection of circulating tumor cells promotes precision medicine for cancer
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Circulating tumor cells (CTCs) have the potential to provide genetic information for heterogeneous tumors, which be useful for monitoring disease progression and developing personalized therapies. However, the isolation of CTCs for molecular analysis is

Customizing a Variant Annotation-Support Tool: an Inquiry into Probability Ranking Principles for TREC Precision Medicine .
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Abstract The TREC 2017 Precision Medicine Track aims at building systems providing meaningful precision medicinerelated information to clinicians in the field of oncology. The track includes two tasks: 1) retrieving scientific abstracts addressing treatment effect and Purpose To determine whether published disease penetrance estimates of 50% for pheochromocytoma and 20 30% for primary hyperparathyroidism in multiple endocrine neoplasia (MEN 2A), conceivably reflecting overrepresentation of index patients with

Biospecimen sharing among Hispanic women in a safety-net clinic: implications for the precision medicine initiative
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Biospecimen donation is key to the Precision Medicine Initiative, which pioneers a model for accelerating biomedical research through individualized care. Personalized medicine should be made available to medically underserved populations, including the large and Ovarian clear cell carcinoma (OCCC) is a histological subtype of epithelial ovarian carcinoma prevalent in Asians. No clear therapeutic selection based on molecular profile has been implemented for this disease. Oncogenic PIK3CA mutation, which activates the With the ascendance of large genomic biobanks that leverage healthcare systems and provide access to DNA, biospecimens and electronic health record (EHR) data, epidemiologists can now conduct population science research at scale in individual cohorts

On the brink of precision medicine for psychosis: treating the patient, not the disease: a commentary on: association between serum levels of glutamate and
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With major scientific developments, precision medicine for psychiatry holds the promise for psychosis prevention and accurate prediction of individual treatment response, bringing hope for much needed effective and safe customized treatments. Although, biologically

Predicting longevity using metabolomics: a novel tool for precision lifestyle medicine
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Conclusions Could our patients lifestyle habits and associated health consequences be captured in risk evaluation by metabolomics biomarkers (Fig. 1) Furthermore, could high- throughput metabolomics provide an opportunity to not only estimate mortality with greaterMultiple myeloma (MM) is a challenging, progressive, and highly heterogeneous hematological malignancy. MM is characterized by multifocal proliferation of neoplastic plasma cells in the bone marrow (BM) and sometimes in extramedullary organs. Despite the

Exploring a deep learning pipeline for the BioCreative VI precision medicine task
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The BioCreative VI Track IV (Mining protein interactions and mutations for precision medicine ) challenge is presented to support the Precision Medicine Initiative with the goal of applying biomedical text mining methods to extract interacting protein pairs that are affected

Laboratory and precision medicine : the reasons for the birth of a new journal
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4. Smith KL, Isaacs C. BRCA mutation testing in determining breast cancer therapy. Cancer J 2011; 17: 492-9. 5. Plebani M, Lippi G. HER2: Closing the gap between laboratory testing and clinical practice. Am J Clin Pathol 2009; 131: 897-8; author reply 898-900. 6. Lippi G

Internet of Medical Imaging Things and Analytics in Support of Precision Medicine for the Case Study of Thyroid Cancer Early Diagnostics
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In this paper the role of advanced IT technologies such as Internet of medical imaging Things and analytics in support and promotion of precision medicine has been revealed considering the case study of early thyroid cancer diagnostics. The concept of precision

A path for precision medicine
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For three years, Dr. Robert Green, a researcher at Brigham and Womens Hospital and Harvard Medical School, has been painstakingly gathering genetic data on thousands of Alzheimers patients, trying to figure out whether genetic differences explain why the disease The human body immune system, metabolism and homeostasis are affected by microbes. Dysbiosis occurs when the homeostatic equilibrium is disrupted due to an alteration in the normal microbiota of the intestine. Dysbiosis can cause cancer, and also affect a patients

Precision Medicine for Aortic Stenosis: The Future of Cardiology Today
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Despite all our success in cardiology, we are still, in some ways, working at an obtuse level. We try and find individual markers for disease pathology (1), risk (2), or for triaging patients for certain therapies (3), and when that is not possible, we create small multivariable

Technical background for a precision medicine approach to develop optimal exercise and weight loss treatments for overweight and obese adults with knee
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This technical report provides additional statistical background for the methodology developed in the clinical analysis of knee osteoarthritis in Jiang et al.(2020). Jiang et al.(2020) proposed a pipeline to learn optimal treatment rules with precision medicine

Advancing American Kidney Health (AAKH): Catalyst for Investment in Kidney Diseases Clinical Trials and Precision Medicine : An Opportunity to Advance Upstream
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KJ Fowler Clinical Journal of the American Society of Nephrology Am Soc Nephrol On July 201 President Trump issued the Executive Order (EO) on Advancing American Kidney Health (AAKH). I was invited to this historic announcement in Washington, DC, along with my Kidney Health Initiative, Patient Family Partnership Council colleagues. I never

Review of monoclonal antibody therapies in asthma and allergic diseases-a new paradigm for precision medicine
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Background: Elucidation of the critical immune pathways involved in allergic inflammation has identified, apart from IgE, therapeutic targets in the cytokine network suitable for intervention by biological therapies. Objective: The drugs that target the cytokine networks

Advancing precision medicine for the treatment of long-QT syndrome type 2: shedding light on lumacaftor
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Congenital long-QT syndrome (cLQTS) typically prolongs the QT interval on an electrocardiogram (ECG) to increase the risk for ven- tricular arrhythmias including the potentially fatal tachyarrhythmia Torsades de Pointes (Take home figure A). 2 The autosomal dominant form of cLQTS (originally

Exploring how to Combine Query Reformulations for Precision Medicine .
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We report on our participation as the IMS Unipd team in both TREC PM 2019 tasks. The objective of the work is twofold:(i) we want to evaluate how different query reformulations affect the results and whether the findings obtained in previous years remain valid;(ii) we

What is precision genomic testing?
At IU Health, precision genomic testing will look at the genetic structure of your tumor. This helps us discover “actionable” mutations that can be targeted with therapy. These discoveries can lead to new treatment recommendations that may effectively treat your cancer on a personalized level.