what is coronavirus
Coronavirus disease (COVID-19) is an infectious disease caused by a newly discovered coronavirus.
Most people who fall sick with COVID-19 will experience mild to moderate symptoms and recover without special treatment.
HOW IT SPREADS
The virus that causes COVID-19 is mainly transmitted through droplets generated when an infected person coughs, sneezes, or exhales. These droplets are too heavy to hang in the air, and quickly fall on floors or surfaces.
You can be infected by breathing in the virus if you are within close proximity of someone who has COVID-19, or by touching a contaminated surface and then your eyes, nose or mouth.
Coronavirus spike proteins in viral entry and pathogenesis
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Coronaviruses comprise a large and diverse family of enveloped, positive-stranded RNA viruses. The Coronaviridae exhibit broad host range, infecting many mammalian and avian species and causing upper respiratory, gastrointestinal, hepatic, and central nervous system
Novel Coronavirus situation report, 3
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WHO has been in regular and direct contact with Chinese as well as Japanese, Korean and Thai authorities since the reporting of these cases. The three countries have shared information with WHO under the International Health Regulations. WHO is also informing[HTML]
Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR
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Background The ongoing outbreak of the recently emerged novel coronavirus (2019-nCoV) poses a challenge for public health laboratories as virus isolates are unavailable while there is growing evidence that the outbreak is more widespread than initially thought, and
Coronavirus disease 2019 (COVID-19): situation report, 72
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WHO has released a scientific brief on the off-label use of medicines for COVID-19. A number of medicines have been suggested as potential investigational therapies, many of which are now being or will soon be studied in clinical trials, including the SOLIDARITY trial
Assays for laboratory confirmation of novel human coronavirus (hCoV-EMC) infections
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We present a rigorously validated and highly sensitive confirmatory real-time RT-PCR assay (1A assay) that can be used in combination with the previously reported upE assay. Two additional RT-PCR assays for sequencing are described, targeting the RdRp gene
The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) China
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Background: An outbreak of 2019 novel coronavirus diseases(COVID-19) in Wuhan, Hubei Province, China has spread quickly nationwide. Here, we report results of a descriptive, exploratory analysis of all cases diagnosed as of February 1 2020. Methods: All COVID-19
Chloroquine for the 2019 novel coronavirus
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Page 1. Journal Pre-proof Chloroquine for the 2019 novel coronavirus Philippe Colson Jean-Marc Rolain Didier Raoult PII: S0924-8579(20)30066-2 DOI: https://doi.org/10.1016/ j.ijantimicag.2020.105923 Reference: ANTAGE 105923 To appear in: International Journal
Epidemiological characteristics of 2143 pediatric patients with 2019 coronavirus disease in China
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OBJECTIVES: To identify the epidemiological characteristics and transmission patterns of pediatric patients with COVID-19 in China. METHODS: Nationwide case series of 2143 pediatric patients with COVID-19 reported to the Chinese Center for Disease Control and
Adoptive transfer of EAE-like lesions from rats with coronavirus -induced demyelinating encephalomyelitis
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Viruses have been found to induce inflammatory demyelinating lesions in central nervous system (CNS) tissue of both animal and man, either by natural infections or after vaccination 2. At least two different pathogenic mechanisms have been proposed for these changes, a
Coronavirus disease 2019 (COVID-19): situation report, 70
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WHO has updated the operational planning guidelines to help countries maintain essential health services during the COVID-19 pandemic. The document includes a set of immediate actions that countries should consider at national, regional, and local level to reorganize and
Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection
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Background: Since September 201 170 confirmed infections with Middle East respiratory syndrome coronavirus (MERS-CoV) have been reported to the World Health Organization, including 72 deaths. Data on critically ill patients with MERS-CoV infection are limited
Recovery from severe novel coronavirus infection
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The nsp9 replicase protein of SARS- coronavirus , structure and functional insights
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As part of a high-throughput structural analysis of SARS- coronavirus (SARS-CoV) proteins, we have solved the structure of the non-structural protein 9 (nsp9). This protein, encoded by ORF1a, has no designated function but is most likely involved with viral RNA synthesis. The
Incubation period of 2019 novel coronavirus (2019-nCoV) infections among travellers from Wuhan, China, 20 28 January 2020
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A novel coronavirus (2019-nCoV) is causing an outbreak of viral pneumonia that started in Wuhan, China. Using the travel history and symptom onset of 88 confirmed cases that were detected outside Wuhan in the early outbreak phase, we estimate the mean incubation
Mutational analysis of the RNA pseudoknot component of a coronavirus ribosomal frameshifting signal
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The genomic RNA of the coronavirus IBV contains an efficient ribosomal frameshift signal at the junction of the overlapping la and lb open reading frames. The signal is comprised of two elements, a heptanucleotide slip-site and a downstream tertiary RNA structure in the form
Amino acids within hypervariable region 1 of avian coronavirus IBV (Massachusetts serotype) spike glycoprotein are associated with neutralization epitopes
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Extensive antigenic variation is a feature of IBV and new serotypes, based on neutralization tests, have been detected frequently (Cook and Huggins, 1986). Only recently has the molecular basis for this variation been sought. Most attention has been focused on the spike
Murine coronavirus infection: a paradigm for virus-induced demyelinating disease
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A variety of neurological diseases in humans, including multiple sclerosis (MS), have been postulated to have a viral etiology. The use of animal models provides insights into potential mechanism (s) involved in the disease process. The murine coronavirus -induced
Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission
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The occurrence of concentrated pneumonia cases in Wuhan city, Hubei province of China was first reported on December 2019 by the Wuhan Municipal Health Commission (WHO). The pneumonia cases were found to be linked to a large seafood and animal
Sequence and topology of a model intracellular membrane protein, E1 glycoprotein, from a coronavirus
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In the eukaryotic cell, both secreted and plasma membrane proteins are synthesized at the endoplasmic reticulum, then transported, via the Golgi complex, to the cell surface 1 4. Each of the compartments of this transport pathway carries out particular metabolic functions 5 8
Biological properties of avian coronavirus RNA
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Table i. Binding of different RNAs to oligo (dT)-cellulose Non-bound Bound RNA preparation Total ct/min ~ of total ~ of total IBV I I56oo I7 83 Table 2. Properties of infectious virus RNAs in comparison to IBV IBV RNA None CEK 27 x I07 IBV RNA None L cell 5ox IO IBV