artificial pancreas



Modeling and control of diabetes: Towards the artificial pancreas
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The paper offers a survey of some major simulation and control issues associated with the development of an Artificial Pancreas . The main topics include the role of large-scale simulation models used to carry out in silico trials, the discussion of the specific features of Dear Sir, There is an increasing body of evidence to suggest that patients with diabetes mellitus have accelerated atherosclerotic vascular disease which seems primarily dependent on endothelial injury [l]. An increased sensitivity to platelet aggregating agents

A closed loop implantable artificial pancreas using thin film nitinol MEMS pumps
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To prevent the onset of serious pathologies diabetics must maintain extremely close control over their glucose levels which requires as many as eight blood samplings a day, an onerous task. A long sought solution is to have glucose monitored by an implantable sensor

A closed-loop artificial pancreas based on MPC: human-friendly identification and automatic meal disturbance rejection
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Type 1 diabetes is characterized by a lack of insulin production from the pancreas, causing high blood glucose concentrations and requiring external insulin infusion to regulate blood glucose. A novel procedure of human-friendly identification testing using multisine inputs is

Real-time detection of Glucose Sensor and Insulin Pump Faults in an Artificial Pancreas .
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Sensors for real-time continuous glucose monitoring (CGM) and pumps for continuous subcutaneous insulin infusion (CSII) have opened new scenarios for Type 1 diabetes treatment, including the development of an Artificial Pancreas , a minimally invasive device

Glucagon and blood glucose: Insights from artificial pancreas studies
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The central role of insulin in the pathogenesis of diabetes has been recognized since the classical experiments of Banting and Best in 1921. Subsequent studies, however, have clearly shown that other hormones also contribute to the regulation of blood glucose. The

A constrained model predictive controller for an artificial pancreas
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A Constrained Model Predictive Control (CMPC) approach for regulating blood-glucose levels in people with type 1 Diabetes is proposed. The controller uses the past suggested insulin, the subcutaneous glucose level, and an estimation of the carbohydrate amount of

Hybrid online sensor error detection and functional redundancy for artificial pancreas control systems
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Artificial pancreas (AP) control systems rely on signals from glucose sensors to collect glucose concentration (GC) information from people with Type 1 diabetes and compute insulin infusion rates to maintain GC within a desired range. Sensor performance is often

From pancreatic extracts to artificial pancreas : history, science and controversies about the discovery of the pancreatic antidiabetic hormone. IV: Frederick
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Most relevant pioneer works were carried out by Georg L. Zuelzer and Israel S. Kleiner. On June 21 and June 22, 1906, Zuelzer injected subcutaneously his pancreatic extract to a comatose adult diabetic subject who showed an impressive transient recovery. As there was

Design and development of a mechatronic system for noninvasive refilling of implantable artificial pancreas
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The aim of this study is to contribute to the ad-vancement of the mechatronic implantable artificial organs field by demonstrating the feasibility of a mechatronic refilling module to be used with implantable artificial organs (and particularly suitable for an artificial pancreas )

Live demonstration: A handheld Bio-inspired Artificial pancreas for treatment of diabetes
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Good control of glucose in diabetes requires minimisation of high and low blood glucose excursions and is critical to reducing the incidence of complications and improving quality of life. A closedloop insulin delivery system consisting of a glucose sensor, a controller and an

Actuator fault tolerant control for an artificial pancreas
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With recent advances in continuous glucose sensors and portable insulin pumps, the concept of an artificial pancreas is now feasible. However, due to continuous operation, the actuator in this system could fail in some degree. In this sense, this paper addresses model Five years ago, we started to reestablish normoglycemia in diabetics by technical means (1-2). The artificial endocrine pancreas, developed at the University of Ulm in collaboration with Mr. AH Clemens from Life Science Instruments, Miles Laboratories, Inc., Elkhart, Ind. (USA), is

The artificial pancreas in 2017: The year of transition from research to clinical practice
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In this trial, the insulin requirements of each participant (basal rate settings and carbohydrate ratio) were adapted every week using an adaptation algorithm. Consistent with the pilot nature of this study, the adaptation of these critical parameters had to be confirmed by a

A bio- artificial pancreas created using cell encapsulation in self-assembled microcontainers on alginate sheet
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This paper presents a bio- artificial pancreas fabricated with self-assembled, precisely structured 3D microcontainers on a rolled-up alginate sheet. We utilize a novel 3D membrane approach developed in our laboratory to package pancreatic βcells so that they

Clinical evaluation of the bio-inspired artificial pancreas (BiAP) without meal announcement in adults with type 1 diabetes
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Page 1. BACKGROUND and OBJECTIVESThe Bio-inspired Artificial Pancreas (BiAP) uses a control algorithm (Fig 1) based on a mathematical model of beta-cell physiology and is implemented in a microchip within a handheld device (Fig 2).1,2We have previosusly

Susceptibility enhanced imaging of bioengineered constructs for an artificial pancreas
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SC Grant1, SJ Blackband1, H. Mao2, J. Oca-Cossio3, NE Simpson3, I. Constantinidis3 1Neuroscience, University of Florida McKnight Brain Institute, Gainesville, FL, United States, 2Radiology, Emory University School of Medicine, Atlanta, GA, United States, 3Medicine

Normalization of growth hormone hypersecretion in uremic diabetics and non-diabetics. Studies with artificial pancreas and artificial kidney
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Haemodialysis of diabetic patients is often complicated by serious electrolyte and metabolic abnormalities occurring during as well as after dialysis. The aim of the present investigation was to study the occurrence and dynamics of these abnormalities. The problems

Sampled-data observer-based glucose control for the artificial pancreas
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Artificial Pancreas (AP) is an expression referred to a set of techniques for the closed-loop control of the plasma glucose concentration by means of exogenous insulin administration in diabetic patients. Diabetes comprises a group of metabolic disorders characterized by

A physicians decision-making process in prescribing an artificial pancreas is influenced by their perceived social expectations of patients.
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There is a vast literature on technology acceptance and the intention to use new technologies for specific groups of people. However, the current works provide contrasting evidence of the influence of the subjective norm on the intention to use a new technology



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