INFLUENCE OF PHARMACOLOGICAL CORRECTION ON THE QUALITY OF LIFE OF CHILDREN WITH FUNCTIONAL DYSPEPSIA

Marina Mamenko, Hanna Drokh

Objective: To study the influence of pharmacological psychocorrection with drugs derived from GABA on the quality of life of primary school-aged children with functional dyspepsia.

Materials and methods. 80 children aged 6–12 years with FD have been examined. Children were divided into 4 groups: Group 1 – 20 patients who received γ-amino-β-phenylbutyric acid hydrochloride along with baseline therapy, Group 2 – 20 patients who received comprehensive treatment and calcium hopantenate, Group 3 – 20 children who received vitamin-mineral complex and protocol treatment, and Control Group – 20 children who received baseline treatment. Study Design: general clinical, instrumental, psychodiagnostic, statistical.

Results. Using the PedsQL questionnaire, physical functioning disorders were found in children with FD – 97.5±1.2 % (78/80) of children, emotional functioning disorders – 91.3±1.6 % (73/80) of cases, functioning at school disorders – 88.8±2.7 % (71/80) of patients. During one-month case monitoring, children who took GABA drugs reported an improvement in the quality of life compared with baseline treatment and a group of children, who took a mineral-vitamin complex: physical functioning – (р₁=0,016), (р₂=0,03), emotional functioning – (р₁˂0,001), (р₂˂0,001), functioning in school – (р₁=0,005), (р₂=0,004).

Conclusion. The use of γ-aminobutyric acid drugs is safe and effective and they significantly improve the quality of life of children with FD.