biochip engineering research papers





Rapid protein display profiling of cancer progression directly from human tissue using a proteinbiochip
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ABSTRACT The complicated, changing pattern of protein expression should contain important information about the pathologic process taking place in the cells of actual tissue. targets could be possible if a

Direct microcontact printing of oligonucleotides for biochip applications
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Abstract Background: A critical step in the fabrication of biochips is the controlled placement of probes molecules on solid surfaces. This is currently performed by sequential deposition target surface with split or solid pins. In this article, we present a cost-

Biochip sensors for the rapid and sensitive detection of viral disease
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Abstract Recent advances in DNA and protein microarray methodology and the emerging technology of cellbased sensors have massively increased the speed and sensitivity with which we can detect viral infections. The advantages of the multi-parameter microarray

Ontology-based semantic annotations for biochip domain
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The documents published on the Web represent a very important source of knowledge which is essential for checking, validating and enriching a research work. It is the case of research in the domain of molecular biology and more particularly in the domain of biochip translated or copied in whole or in part without the written permission of the publisher

Biochip platforms as functional genomics tools for drug discovery
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At the present time the pharmaceutical industry faces an upswing in research and development costs, whilst the number of novel molecular entities reaching the market grows at a significantly slower rate. This has forced the industry to devise and adapt

Systematic evaluation of Surface Plasmon Resonance Imaging biochip reader. Study of gold surface modification
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Surface Plasmon Resonance (SPR) has been successfully used in accessing information on a variety of molecular interactions and has achieved a wider popularity with the commercial availability of the BiaCore system. A new variation of this technique, SPR Imaging,

Serological diagnosis of autoimmune bullous skin diseases: prospective comparison of theBIOCHIP mosaic-based indirect immunofluorescence technique with
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Abstract Background: Various antigen-specific immunoassays are available for the serological diagnosis of autoimmune bullous diseases. However, a spectrum of different tissue-based and monovalent antigen-specific assays is required to establish the

Impedance spectroscopy and biochip sensor for detection of Listeria monocytogenes
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ABSTRACT Listeria monocytogenes is a deadly foodbome human pathogen. Its ubiquitous nature and its ability to grow at refrigeration temperatures makes this organism a difficult one to control. High-volume processing of food products and poor sanitary conditions of the

Architecture of a portable system based on a biochip for DNA recognition
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Abstract:This paper presents an architecture for a portable system based on a magnetoresistive biochip microarray for DNA recognition or microorganism/cell identification. In this biochip,targets are labeled with magnetic nanoparticles

Detection of Bacillus anthracis using multiplex PCR on the oligonucleotide biochip
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DETECTION OF Bacillus anthracis 385 which is lacking in B. anthracis and B. thuringiensis. The C by A point substitution at position 1005 is species-specific of B. thuringiensis and some B. cereus strains, such as NCTC9620 (GenBank Ac. No. AF155952), WS2614 ( Atomic Force Microscopy has been used to investigate and characterise endometrial cancer cells and LH-secreting cells, namely gonadotrophs, of the pituitary. Using nanoscale resolution of the AFM features associated with exocytosis events in each cell type are

Self-contained, integrated biochip system for sample-to-answer genetic assays
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Abstract Microfluidics-based biochip devices are developed to perform DNA analysis from complex biological sample solutions. Microfluidic mixers, valves, pumps, channels, chambers, heaters, and DNA microarray sensor are integrated to perform magnetic bead-

A Novel Single-Fault Detection Technique of Digital Micro-Fluidic Biochip
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Abstract:A novel, efficient, single fault detection technique of a digital microfluidic based biochip is presented in this paper. The proposed methodology is based on parallel scanning of the microfluidic biochip by using multiple droplets. The traversal of micro-array is carried

Temperature Simulation and Control of a Biochip for DNA Analysis
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Abstract:This paper presents the preliminary work on the analysis of the thermal behavior of a biochip for DNA detection. The aim is to have a chip with different zones, allowing the possibility to perform experiments at the same time but with independent temperature

Biochip spots single viruses
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The researchers' prototype uses antibody proteins attached to the nanowires to briefly capture individual virus particles." The binding causes a change in the current of the nanowire-based electronic device, which signals the virus presence," said Charles Lieber,

Detection of DNA hybridization on a configurable digital microfluidic biochip using SPR imaging
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ABSTRACT This paper presents a configurable digital microfluidic-based surface plasmon resonance (SPR) biochip platform comprising an electrowetting-on-dielectric (EWOD) microfluidic device coupled to SPR imaging (SPRi). We demonstrate its application for

Evaluation of serum levels of multiple cytokines and adhesion molecules in patients with newly diagnosed acute lymphoblastic leukemia using biochip array
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Aim: Evaluation of serum levels of 17 cytokines and 5 adhesion molecules in patients with acute lymphoblastic leukemia (ALL) and in healthy subjects using biochip array technology.

Total Internal Reflection-Based Biochip For High Throughput Bioassays
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ABSTRACT The construction of a total internal reflection-based biochip utilizing an integrated micromirror array is presented. The evanescent field that dramatically increases the signal to noise ratio, is generated through the implementation of a four-layer chip,

Better known for business acumen than scientific smarts, Hong Kong is betting on biotech as a new pillar industry; a novel biochip suggests it's on the right
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HONG KONG In 1994, neuroscientist Albert Cheung-Hoi Yu gave up a plum position at Stanford University to join the new Hong Kong University of Science and Technology (HKUST). The career gamble paid off in an unexpected way. In 1997, H5N1 avian influ- enza hammered Hong

Single crystalline silicon (SCS) micromirror array for maskless photolithography in biochipfabrication systems
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Abstract Maskless photolithography in biochip fabrication systems has been performed using a single crystalline silicon (SCS) micromirror array for protein microarray synthesis. All structural parts of a micromirror are made of SCS to improve mechanical and optical

Simultaneous Detection of Six Different Groups of Antimicrobial Drugs in Porcine Oral Fluids Using A Biochip Array-Based Immunoassay
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Summary The objectives of this study were 1) to determine whether a biochip array-based immunoassay could be used to detect 6 different group antimicrobials in porcine oral fluids collected under experimental conditions; 2) to determine the feasibility of antimicrobial

Biochip array technology and evaluation of serum levels of multiple cytokines and adhesion molecules in patients with newly diagnosed acute myeloid
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BIOCHIP ARRAY TECHNOLOGY AND EVALUATION OF SERUM LEVELS OF MULTIPLE CYTOKINES AND ADHESION MOLECULES IN PATIENTS WITH NEWLY DIAGNOSED ACUTE MYELOID LEUKEMIA JM Horacek1,2,*, T. Kupsa1,2, M. Vasatova3, L. Jebavy1,2, P.

Biochip-Based Test System for Cancer Diagnostics. Simultaneous Quantitation of Total and Free Forms of Prostate-Specific Antigen
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ABSTRACT Diagnostic performance of biochip-based test-system for simultaneous quantitation of two forms of prostatespecific antigen (PSA) in human serum was evaluated and compared to efficacy of ELISA test-system (CanAg). Regression analysis revealed a

Fabrication of biochip based on CD/DVD manufacturing technology
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ABSTRACT: Biochip is a kind of nano/microfluidic chip based on biology system. All advanced microfluidic are moving into small micro-meter and nano-meter scale and need a low cost and high production manufacturing method. The history and situation of biochips

Biochip and Cancer Diagnosis
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1. Oh, SJ, Ju, J., Kim, BC, Ko, E., Hong, BJ, Park, J.-G., Park, JW and Choi, KY DNA microarrays on the dendron surface improve significantly the detection of single nucleotide variations in p53 gene Nucleic Acids Research 2005, 33, e90. 2. Hong, BJ, Oh, SJ, Youn, TO, Kwon,

Method validation for simultaneous determination of 12 sulfonamides in honey using biochiparray technology
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Abstract A new method for simultaneous multi-analyte determination of drug residues in honey samples was validated according to the criteria set by the Commission Decision 2002/657/EC.Antimicrobial Array I, An immunoassay based on multi-analyte array for

Factors affecting biochip design for cancer early detection
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Introduction lifestyle changes and progresses in medical treatments have led to an impressive increase in life expectancy during the past three decades. Cancer, one of the major causes of premature morbidity and mortality in the developed world, is a chronic

Droplet routing simulation for digital microfluidic biochip
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Abstract Microfluidics based biochips are used for different clinical diagnosis, massive parallel DNA sequencing, automated drug discovery and real time bio-molecular recognition. Mainly two types of microfluidics based biochips are used these days. They

Novel 3-D all-polymer high collection efficiency pathogen detection biochip
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Many advanced technologies in this rapidly evolving world are moving towards miniaturization of products. In earlier days, giant computers which occupied a huge room were considered a novelty compared to today's trends in technology of products that has

APPLICATION OF AN EVIDENCE BIOCHIP ARRAY TO THE SIMULTANEOUS DETERMINATION OF CYTOKINES RELATED TO INFLAMMATION
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Conclusions Data shows applicability of this biochip array to the simultaneous detection of twelve cytokines on the fully automated Evidence analyser. A patient profile is generated, which can provide more information on complex interactive networks than single analyte

IMMUNOASSAYS FOR tHE DEtERMINAtION OF DRUGS OF ABUSE IN WHOLE BLOOD ON ABIOCHIP PLAtFORM: COMPARISON OF ANALYtICAL PARAMEtERS
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Evidence biochip array technology provides a platform for the simultaneous screening of drugs of abuse from a single whole blood sample. The core of the technology is the biochip (9mm x 9mm) and represents not only the platform in which the capture ligands are

A POLYMER BIOCHIP FOR DETECTING INORGANIC AND ORGANIC PHOSPHATE USING PLANAR COBALT MICROELECTRODES
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Abstract In this work, a low-cost, miniaturized, multi-analyte polymer biochip, which can be used for measuring inorganic (H2PO4-) and organic phosphate compounds (adenosine 5'- triphosphate, ATP and adenosine 5'-diphosphate, ADP), and pO2 has been designed,

Biochip-Technologies
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Page 1. IMTEK powerpoint template 2008: Version 2 of the first slide Biochip-Technologies T. Brandstetter Page 2. Page 11. T. Brandstetter/ 09.05.2014 / slide 11 www.imtek.de/cpi Biochip materials (1) Microscope slide of glass Commercial microscope glass slides

Excimer laser micromachining technology in biochip
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ABSTRACT This paper briefly introduce our work on new biochip manufacuring utilizing excimer laser micromachining. The experiment results shows, that this technology have potentials in actual microstructure forming, processing way, manufacturing cost, efficiency,

Biochip Technologies (2) Biochip-Technologies (2)
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Architecture of a Portable System Based on a Biochip for DNA Recognition M. Piedade, L. Sousa, J. Germano, J. Lemos, B. Costa, INESC-ID/IST, R. Alves Redol, 9, 1000-029, Lisboa,

Biofunctional core-shell nanoparticle deposition for biochip creation by printing processes
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ABSTRACT In order to set up an automated production-line for nanoparticle-based bio- chips, a piezo driven ink-jet printing process was developed which is biocompatible and

Development of a micro biochip integrated traveling wave
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Abstract Since most of miniaturized surface plasmon resonance (SPR) sensing systems need commercially available peristaltic or syringe pumps, it is difcult to reduce the system size, biosample volume, and the production cost. In this paper, a compact biochip for

Calibration Method of Biochip Temperature Sensors
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Abstract. Currently, a microanalysis technology is employed in detection systems in fields such as medical science, food safety, and environmental monitoring, and it is being developed in the form of a lab-on-a-chip. However, the reproducibility and sensitivity of

Multiple USB Webcam Link Control System for Reading QR Codes of Micro PCR BiochipCalibration Factor Values
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Abstract Detection systems in a range of fields including medical science, food safety, and environmental monitoring use miniaturized polymerase chain reactions that have lab-ona- chip technologies. The chip used for a micro PCR needs the correction factor of the chip

Biochip based non-equilibrium melting curve analysis of Hepatitis B virus mutation
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Abstract: Oligonucleotide biochips are increasingly used in diagnostics for genetic diseases and pathogen detection in recent years. Because of the different duplex stability caused by wide range of GC contents, it is difficult to simultaneously distinguish single nucleotide

Simulations to prepare a biochip irradiation experiment on ISS
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A. Le Postollec1, M. Baqué2, G. Coussot3, L. Desorgher4, M. Dobrijevic1, S. Incerti5, A. Mantero5, P. Moretto5, P. Nieminen6, 1 Université Bordeaux 1, CNRS, OASU, Laboratoire d'Astrophysique de Bordeaux (LAB), UMR 5804, Floirac, 2 Institut des Biomolécules

DETERMINATION OF AMPHETAMINE IN WHOLE BLOOD USING EVIDENCE BIOCHIP ARRAY TECHNOLOGY: ANALYTICAL PARAMETERS COMPARISON WITH
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Evidence biochip array technology provides a platform for the simultaneous screening of drugs of abuse from a single whole blood sample. Miniaturised simultaneous

Infection. J Biochips Tiss Chips 2: e115. doi: 10.4172/2153-0777.1000 e115 Page 2 of 2 Volume 2 Issue 4 1000e115 J Biochip Tissue chip ISSN: 2153-0777
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Animal models are commonly used to study the pathogenesis of infection and to evaluate the effectiveness of treatments in combating infection. However, microbial infection in laboratory animals may also exert a devastating effect on animal healthcare. Many

FULLY-AUTOMATED ELECTROCHEMICAL BIOCHIP PLATFORM FOR RAPID, SIMULTANEOUS AND SENSITIVE BIOAGENT DETECTION
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The anthrax or ricin findings in the US postal system clarified the urgent need to develop rapid, sensitive and specific detection systems for biothreat agents. Here, we present a fully- automated electrochemical detection platform (portable toxin detector, pTD) for universal

Breath Acetone Analyzer to Achieve Biochip Mobile Terminal
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Accounting for the greater part of national medical expenditure, general medical costs have been steadily increasing in recent years. About one third of these costs are due to lifestylerelated illnesses [1]. Lifestyle-related illnesses are diseases such as cancer, heart

Integration of Polymerase Chain Reaction in a Magnetoresistive Biochip
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Integration reported. The calibration of magnetoresistive (MR) sensors as temperatures sensors have been studied in order to evaluate the system thermal parameters and ensure a temperature cycling system required for an optimal PCR reaction. A Pulse Width

On the Effect of Substrate Compliance on Cellular Motility. J Biochip Tissue Chip 1: 101. doi: 10.4172/2153-0777.1000101
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Abstract Recent in vitro studies have highlighted the importance of substrate stiffness in governing a range of cellular functions. Motility of adherent cells, in particular, is found to be regulated by the substrate rigidity. Many cell types exhibit a subtle biphasic migration-

Silicon nitride photonic crystal nanocavities for biochip applications
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ABSTRACT We show that Silicon Nitride (Si3N4) photonic crystal (PhC) resonators are powerful building blocks to realize biocompatible photonic devices based on spontaneous emission engineering of nanoemitters in the visible spectral range. The versatility of this

RAPID MULTIPLEX SNP GENOTYPING USING BIOCHIP ARRAY TECHNOLOGY
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Conclusions The Randox Biochip array platform can rapidly genotype 8 SNPs in a single PCR reaction. The platform therefore has wide ranging applicability in the field of personalised medicine and can aid the clinician in selecting the right drug for the right

Biochip for minimally invasive blood glucose monitoring
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ABSTRACT The most common techniques for blood glucose sensing are based on enzymatic glucose oxidation techniques because of being highly sensitive and specific to the glucose. But, the techniques need oxygen environment and the measurement

Regional Trajectories, Geographical Proximity and the Bridging of Technological Distances: the Example of the Biochip Industry in Germany
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Abstract: It is argued that the crucial process in the emergence and convergence of regional trajectories is the movement of the single firm through the technological space. When the development of regional trajectories is place dependent, this movement should be

DETERMINATION OF TETRAHYDROCANNABINOL IN WHOLE BLOOD USING EVIDENCEBIOCHIP ARRAY TECHNOLOGY: ANALYTICAL PARAMETERS
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Evidence biochip array technology provides a platform for the simultaneous screening of drugs of abuse from a single whole blood sample. Miniaturised simultaneous

ANCA IFA Granulocyte BIOCHIP Mosaic Test System 2 Test instructions
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Intended use: The EUROIMMUN ANCA IFA Granulocyte BIOCHIP Mosaic Test System 4 is intended for the qualitative or semi-quantitative determination of anti-neutrophil cytoplasmic antibodies (ANCA) in serum. The test is used as an aid in the diagnosis of

Biochip analysis of prostate cancer
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ABSTRACT. Microarray expression analysis was used to forecast the roles of differentially co-expressed genes (DCG) and DCG and links in the pathogenesis of prostate cancer. In addition, we demonstrate that the relationship between transcriptional factors (TFs) and

Fortification of Multiple Parallel Assay Operations with Cross Contamination Avoidance in a Restricted Biochip
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Abstract:Digital microfluidic biochips are modification many areas of Biochemistry, Biomedical sciences, and Microelectronics. It is also known as 'Lab-on-a-Chip'for its recognition as an alternative to laboratory experiments. In recent times, because of

A Common Data Representation for Organizing and Managing Annotations of BiochipExpression Data Sudeshna Adak, Biplav Srivastava, Pankaj Kankar
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Abstract This paper describes a systematic method of representation for data related to biochip experiments. The data is either a) gene or protein expression data as obtained from biochip experiments or b) information related to genes and proteins of interest in the

Imaging Ellipsometry: A Powerful Method for Biochip Development, QC and Evaluation
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ABSTRACT Ellipsometry as a well-established method in material research has substantially enriched the field of protein research: A special application known as SPR has widely been accepted as the major tool to characterize the interaction of proteins with all

Metallic Nanoparticles-Based Biochip with Multi-Channel for Immunoassay
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Recently, biochemistry nanosensor is an active research topic in both life sciences and engineering [1]. It involves the interdisciplinary areas of life sciences and information sciences such as bioinformatics, biochemistry chip, bio cybernetics, bionics, and bio-

Laser guidance in a microfluidic biochip
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abstract In this study, we developed a microfluidic biochip to perform laser guidance on two cell types, chick embryonic forebrain neurons and chick embryonic spinal cord neurons. The neurons we obtained from these two cell types have no difference in morphology as

Anti-Coxsackie virus IFA (IgA, IgG or IgM) BIOCHIP Mosaic Test System Test instruction
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Intended use: These kits are intended for the qualitative or semi-quantitative determination of antibodies against Coxsackie virus in human serum and plasma. They are used as an aid in the diagnosis of–amongst other–common colds, meningitis, myo-pericarditis, myositis

Systematic evaluation of a surface plasmon resonance imaging biochip reader: study of gold surface modifications (II)
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The use of the Surface Plasmon Resonance phenomenon to create a two-dimensional image of a surface has become of importance in the field of proteomics and in the study of the interactions between biomolecules. One of the most critical steps in the preparation of

A Multipurpose EIS Biochip for Pathogenic Bacteria Detection
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Abstract Despite the improved awareness for food safety and security worldwide, and the great advances in diagnostics, food borne illnesses caused by the ingestion of foods contaminated with pathogens and/or their toxins are still one of the major public health

Monte-Carlo simulation of a biochip irradiation during a Mars mission
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A biochip is composed of biological sensitive systems called ligands (like antibodies) fixed on a slide, which allow the detection of specific organic molecules, called biomarkers. In the case of measurements on site (from samples extracted from the planetary soil) the main

Development of a micro biochip integrated traveling wave micropumps and surface plasmon resonance imaging sensors
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Abstract Since most of miniaturized surface plasmon resonance (SPR) sensing systems need commercially available peristaltic or syringe pumps, it is difficult to reduce the system size, biosample volume, and the production cost. In this paper, a compact biochip for

APPLICATION OF AN EVIDENCE BIOCHIP ARRAY TO THE SIMULTANEOUS DETERMINATION OF TRICYCLIC ANTIDEPRESSANTS, BUPRENORPHINE, MDMA
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Simultaneous screening of tricyclic antidepressants (TCAs), buprenorphine, Methylenedioxymethamphetamine (MDMA) and other drugs of abuse is relevant for

Application of Magnetic Reading Technology in New Biochip Development
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Abstract Spin-valve sensors, traditionally used in Magnetic Recording/Reading Technology for disk and tape drives were used in the development of a new biochip. This novel approach makes use of the Giant Magneto-Resistive (GMR) effect of the sensor for

SIMULTANEOUS QUANTITATIVE ENDOCRINE IMMUNOASSAYS WITH EVIDENCEBIOCHIP ARRAYS
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Results Biochip Array technology is used to perform the simultaneous quantitative detection of these analytes. Antibodies raised to each hormone are bound to discrete test regions on the biochip surface. A combination of sandwich and competitive chemiluminescent

Key technologies for LSPR-sensing microfluidic biochip
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ABSTRACT New structures of micro-pump, biosensor in LOC (Lab-on-a-Chip) are studied. A round-path-chamber pumping principle is proposed to depress output fluctuation and increase output pressure of micro valve-less mechanical pump. Its prototype produces The Ninth Course of the International School of Biostructure "Toward the Biochip," cosponsored by the Italian Science-Technology Ministry, CNR, FRP (Japan), I1KICS, USA Naval Office, SRG, NSF will be structured in three major topics: 1o Engineering of new proteins of

Anti-Parainfluenza virus types 1-4 IFA (IgA, IgG or IgM) BIOCHIP Mosaic Test System Test instruction
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Intended use: These kits are intended for the qualitative or semi-quantitative determination of antibodies against Parainfluenza virus types 1-4 in human serum and plasma. They are used as an aid in the diagnosis of infections of the respiratory tract and pseudocroup, in

Anti-Bordetella pertussis/Bordetella parapertussis IFA BIOCHIP Mosaic Test System (IgA, IgG or IgM) Test instruction
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Intended use: These kits are intended for the qualitative or semi-quantitative determination of antibodies against Bordetella pertussis and Bordetella parapertussis in human serum and plasma. They are used as an aid in the diagnosis of infections with Bordetella pertussis

Relation between Blood Viscosity and BRC Aggregation measured by Biochip and Ultrasound Imaging System
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Abstract For early detection of cardiovascular disease (CVDs), the understanding of hemorheological properties is necessary because variation of hemorheological characteristics is closely related with CVDs. Under low shear conditions, red blood cells (

Development of 2-D penicillin image biochip using the light addressable potentiometric sensor
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Abstract We developed the two-dimensional LAPS (light addressable potentiometric sensor) image biochip that is available to detect a 2-D distribution of cell concentration and a diffusion velocity of the pathogenic microorganism. In this study, a reaction of the penicillin

A Droplet Clustering and Residue Removal Technique for Cross-contamination Avoidance in Digital Microfluidic Biochip
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Abstract: Progressive research on design automation of digital microfluidic biochip is helping biochips to emerge as an effective alternative for several pathological experiments in the laboratories. This is often deployed for multiplexing several bioassays under optimized

A Versatile BioChip Format Applied to Blood Serology
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Abstract Advances in genomics and proteomics are bringing new strategies for the diagnosis, treatment and prevention of disease. Much of this progress has been achieved through the use of biochips and microarrays that can provide multiple analyses in a single

Bench to Bedside. J Biochips Tiss Chips 2: e113. doi: 10.4172/2153-0777.1000 e113 Page 2 of 2 Volume 2 Issue 3 1000e113 J Biochip Tissue chip ISSN:
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Biosensors are analytical devices that employ a physicochemical transducer to convert a biomolecular interaction event or a stimulusinduced cellular response into a quantifiable signal. With the expansion in transduction strategy and advances in sensor design and

Study of the resistance, in the physical environment of the International Space Station, of abiochip-based instrument designed for astrobiological purposes.
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Biochips present interesting potentialities for the search for life in the Solar System. Biochips are miniaturized devices composed of biological-sensitive systems (like antibodies and aptamers) fixed on a solid substrate allowing trace analysis of organic molecules from

Multi-marker approach with the use of biochip cardiac array technology for early diagnosis in patients with acute coronary syndromes
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Abstract Introduction: Diagnosis of acute coronary syndrome (ACS) is frequently a challenging task while immediate risk stratification remains crucial for the prompt implementation of appropriate therapy in this setting. The prolonged release pattern of

Rapid Identification of a Platelet-Derived Alzheimer's Disease-Specific Phenotype by BiochipArray Technology
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Background: Alzheimer's disease (AD) is a multifactorial neurodegenerative condition and because of the ageing population a growing health problem. The best ante-mortem diagnostics available are neuropsychological assessments and brain imaging. However,

BIOLOGICAL DETECTION LIMIT OF A GMR-BASED BIOCHIP FOR PATHOGENIC ANALYSIS
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Abstract INESC-MN and its collaborators are pursuing the development of an integrated platform where the magnetic sensing unit, the biochemical interface (functionalized organic/inorganic surface), the macro/micro-fluidic system (sample preparation, cell

Universal Platform for Developing an Integrated Biochip or Micro-TAS Based on Electrokinetics
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Abstract This study developed a novel universal platform for developing integrated electrokinetics-base biochips. The purpose of the platform is to provide a standard for modulizing the experiment chip. The chip is using microscope slides (75× 38× 1 mm) as

Enhanced Fluorescence by Controlled Surface Roughness of Plastic Biochip
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Fluoroimmunoassay is one of the protein detection methods in which the most critical parameter is fluorescence intensity as it determines the sensitivity of the analysis. In this study, cyclic olefin copolymer (COC) based plastic biochips of various thicknesses were

GLASS BIOCHIP FABRICATION FOR DNA SEPARATION: SOLVING SOME TECHNOLOGICAL PROBLEMS
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In this article, we suggest solutions tested in our laboratory in order to overcome some common technological problems appearing during glass biochip fabrication for DNA electrophoretic separation. Economical soda-lime slides in place of expensive borosilicate

DEVELOPMENT OF A HIGH SENSITIVITY BIOCHIP ARRAY FOR THE SIMULTANEOUS SCREENING OF TRICYCLIC ANTIDEPRESSANTS, BUPRENORPHINE
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More commonly in the workplace employers are administrating drug screening of urine, blood and saliva samples for monitoring of safety, absenteeism and low productivity. Hair testing for drugs of abuse offers a non-invasive screen with the possibility of drug

A Literature Survey on Pin Configuration and Performance of Some Restricted Sized Digital Microfluidic Biochip
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Abstract-In recent times, microfluidics is expected to lead to sensor systems for high throughput biochemical analysis. One of the most advanced technologies to build a biochip is based on microfluidics where micro/nanoliter droplets are controlled or manipulated to

Optimizing Orthogonal Edge Routing for Microfluidic Biochip Layouts
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Abstract Microfluidic biochips, also called lab-on-a-chip, are currently rising in popularity. This is mostly because they allow biochemical experiments to be carried out on a single, small chip which has a number of advantages. However, the design of these chips is still a

Biochemical Application of IgG Fc-binding peptide:targeted Nano Carrier
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FcBP consisting of 13 amino acids specifically binds to Immunoglobulin G Fc domain. Initially, we utilized this peptide for preparation of antibody chip as a PEG composite for enhanced solubility. After then, the peptide conjugate was immobilized on agarose resin,

Presentation of the Biochip experiment on the EXPOSE-R2 facility aboard the International Space Station
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Biochips present interesting potentialities for the search for life in the Solar System. Biochips are miniaturized devices composed of biological-sensitive systems fixed on a solid substrate that can detect traces of hundreds of organic molecules in complex samples, thanks to

OPTIMIZED ROUTING AND PIN-CONSTRAINED DESIGN OF DIGITAL MICRO-FLUIDICBIOCHIP
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ABSTRACT Digital micro-fluidic biochips have represented as a small integrated tool for large biological sample analysis. Only nanoliter volume of discrete fluid droplets (sample) is required to manipulate the integrated chips on an electrode array via electrical actuation.

Biochip Printing using Virtual Instruments
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The surface of a biochip generally accommodates a few hundred to a few thousand spots (radius: 100-300 µm) with coupled biomolecules. These are created in the form of a matrix (microarray) using a printing system. This special matrix of biomolecules forms the DNA

Screening far red probes for use on optical biochip devices
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targeting and interaction of agents in cellular compartments. A range of novel red excitable fluorescent probes, related to the anthraquinone family of anti-cancer agents, were designed for their DNA

DEVELOPMENT OF A MICROFLUIDIC BIOCHIP FOR ABSORPTION, DISTRIBUTION, METABOLISM AND EXCRETION TOXICOLOGY STUDIES (ADME-TOX)
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Abstract-Absorption, Distribution, Metabolism and Excretion Toxicology studies (ADME-Tox) of Foods and Household Personal Care (HPC) products are carried out systematically under regulation to rule out any health effects. Here we show the development of a microfluidic

Nano well array-based digital biochip platform
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Abstract:-We describe the nanometrics geometry of a well-oriented nanowell (NW) array derived from nanofabrication technology which can easily be employed for digital detection with a high S/N ratio, miniaturization, integrated assays and single molecule analysis. In


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