Levels of specific IgE to auto-strains of s.aureus isolated from locus morbi patients with allergodermatosis
The aim: to determine the levels of specific IgE for S. aureus autostrains isolated from locus morbi with allergic dermatoses.
Research methods: the study included 81 patients who received medical care in the Department of Dermatology, State Institution “Institute of Dermatology on Venereology of the National Academy of Medical Sciences of Ukraine” in 2016-2019. The patients underwent clinical and laboratory examination, which included analysis of complaints and medical history data, assessment of the severity of the disease according to the SCORAD and EASI scales, and bacteriological and immunological studies. Examination of patients was carried out during an exacerbation of the disease.
Results of the study: a correlation was established between the indicators of specific humoral immunity and the clinical course of allergic dermatoses. It was proved that in patients suffering from AD with severe and moderate disease with clinically significant SCORAD indices, IgE reactivity to СCAg auto Staph was significantly higher compared to specific IgE to СCAg reference Staph: 40,5±5,4 and 22,2±3,1 (P <0,01) and 14,9±1,02 and 11,4±1,07 (p<0,01), respectively. When summarizing the results obtained in the study of the blood sera of patients with severe and moderate IE with significant EASI indices, it was shown that the levels of anti-staphylococcal IgE to CCAg auto Staph were significantly higher when compared with serum IgE to CCAg reference Staph: 15,8±1,51 and 11, 7±0,96 (p<0,01) and 8,4±0,48 and 6,9±0,39 (P <0.02), respectively.
Conclusions: given that the determination of specific and total IgE in blood serum blood pressure is included in the clinical protocol for the provision of specialized and highly specialized medical care, and allergen-specific therapy is considered as a promising treatment method, the determination of specific IgE before СCAg auto Staph can provide a personalized approach for diagnosis and treatment allergic dermatoses, weighed down by staphylococcal abnormal colonization of the skin
How to cite paper:
Dzhoraeva, S. (2020). Levels of specific IgE to auto-strains of s.aureus isolated from locus morbi patients with allergodermatosis. ScienceRise: Medical Science, (2 (35), 23–28. https://doi.org/10.15587/2519-4798.2020.198931