Overview of concepts of the sphingolipid metabolism
Sphingolipids are important components of the cell involved in the processes of apoptosis, inflammation, oncogenesis, aging, proliferation, differentiation and growth of cells, as well as in the stress-induced response of cells.
The aim. To study research literature for summarizing the new concepts of sphingolipids biochemical role in the development of various pathological conditions.
Materials and methods. The open sources of scientific literature were analyzed.
Results and discussion. According to the analyzed data, the occurrence of pathologies is associated with the sphingolipid imbalance in cells, and excessive accumulation of ceramides, while by preventing the accumulation of ceramides in cells, it is possible to prevent the appearance of cardiac, neurological and metabolic pathologies, including insulin resistance, heart disease (atherosclerosis, heart failure), as well as hepatic steatosis. Therefore, it is promising to search for drugs that can inhibit individual components of the metabolism of sphingolipids and prevent the development of pathology.
Conclusions. Sphingolipids are involved in numerous processes in cells, and changes in the balance of individual members of this class of lipids can play a crucial role in the development of pathological conditions. At the same time, the accumulated data on disorders of the sphingolipid metabolism in various diseases contribute to the development of drugs based on inhibition of the corresponding components of the metabolism of these lipids.
How to cite paper:
Storozhenko, G., Kharchenko, V., Krasilnikova, O., & Tkachenko, O. (2021). Overview of concepts of the sphingolipid metabolism . ScienceRise: Biological Science, (2(27), 23–27. https://doi.org/10.15587/2519-8025.2021.234699