DIABETIC RETINOPATHY MEDICAL ENGINEERING


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Oxidative stress and diabetic retinopathy
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Oxygen metabolism is essential for sustaining aerobic life, and normal cellular homeostasis works on a fine balance between the formation and elimination of reactive oxygen species (ROS). Oxidative stress, a cytopathic consequence of excessive production of ROS and the

The diaretdb1 diabetic retinopathy database and evaluation protocol.
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For a particularly long time, automatic diagnosis of diabetic retinopathy from digital fundus images has been an active research topic in the medical image processing community. The research interest is justified by the excellent potential for new products in the medical

Serum lipids and diabetic retinopathy
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, Diabetic Retinopathy Study Research Group- Diabetes Am Diabetes Assoc Archives of Ophthalmology, provides an additional reason for lowering elevated serum lipids in patients with diabetes (1). Data from the Early Treatment Diabetic Retinopathy Study (ETDRS) demonstrate that elevated levels of serum lipids are associated with both the

Diabetic retinopathy : an Indian perspective
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Diabetic retinopathy (DR) can be defined as damage to microvascular system in the retina due to prolonged hyperglycaemia. The prevalence of DR in the Chennai Urban Rural Epidemiology (CURES) Eye Study in south India was 17.6 per cent, significantly lower than

Ocular blood flow and associated functional deviations in diabetic retinopathy
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Abbreviations: IOP, Intraocular pressure; LDV, laser Doppler velocimetry; LDF, laser Doppler flowmetry; CDI, colour Doppler imaging; PSV, peak systolic velocity; EDV, end diastolic velocity; RI, resistance index; POBF, pulsatile ocular blood flow; FPA, fundus pulsation

DIARETDB0: Evaluation database and methodology for diabetic retinopathy algorithms
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For a particularly long time, automatic diagnosis of diabetic retinopathy from digital fundus images has been an active research topic in the medical image processing community. The research interest is justified by the excessive potential for new products in the medical

Association of VEGF and eNOS gene polymorphisms in type 2 diabetic retinopathy
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Purpose: Vascular endothelial growth factor (VEGF) is a major mediator of angiogenesis, and nitric oxide (NO) is an upstream and downstream regulator of VEGF mediated angiogenesis. VEGF and NO have been suggested to play an important role in the

Update on the treatment of diabetic retinopathy
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Diabetic retinopathy (DR) is the commonest microvascular complication of diabetes, and remains one of the leading causes of blindness worldwide.1 During the first two decades of disease, nearly all patients with type 1 diabetes and over 60% with type 2 diabetes develop retinopathy . In the

Role of nitric oxide, superoxide, peroxynitrite and PARP in diabetic retinopathy
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Diabetic retinopathy 3. NO, NOS and diabetic retinopathy 3.1. NO and NOS in retina 3.2. NO and NOS in diabetic patients with retinopathy 3.3. NO and NOS studies in experimentally diabetic animals and retinal cells incubated in diabetic -like concentrations of glucose 3.3. 1

Pulsatile ocular blood flow in diabetic retinopathy
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Purpose: To assess circulatory properties of eyes with progressive stages of diabetic retinopathy . Methods: The intraocular pressure, pulse amplitude (PA) and pulsatile ocular blood flow (POBF) were measured with a pneumatonometer (OBF Labs UK Ltd). The eyes

The retinal pigment epithelium: something more than a constituent of the blood-retinal barrier implications for the pathogenesis of diabetic retinopathy
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The retinal pigment epithelium (RPE) is an specialized epithelium lying in the interface between the neural retina and the choriocapillaris where it forms the outer blood-retinal barrier (BRB). The main functions of the RPE are the following:(1) transport of nutrients, ions

A three-year trial of atromid therapy in exudative diabetic retinopathy
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LJP Duncan, JF Cullen, JT Ireland, J Nolan- Diabetes, 1968 Am Diabetes Assoc SUMMARY A three-year trial of Atromid treatment in exudative diabetic retinopathy was carried out in twenty-three patients and twenty-five controls. In comparison with those of the controls the eyes of the Atromid-treated patients showed a highly significant decrease in

The Wisconsin epidemiologic study of diabetic retinopathy
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RESEARCH DESIGN AND METHODS The study population was described in detail in previous reports (24-27). A population-based sample of 990 subjects was selected for examination. This sample was composed of two groups. The first group consisted of all

Diabetic retinopathy analysis
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Diabetic retinopathy is one of the common complications of diabetes. Unfortunately, in many cases the patient is not aware of any symptoms until it is too late for effective treatment. Through analysis of evoked potential response of the retina, the optical nerve, and the

A novel polymorphism in the aldose reductase gene promoter region is strongly associated with diabetic retinopathy in adolescents with type 1 diabetes.
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A (CA) n dinucleotide repeat sequence 2.1 kb upstream of the transcription start site of the aldose reductase gene has been found to be strongly associated with human diabetic nephropathy and retinopathy ( 2) and linked to increased expression of the aldose

Lipid peroxidation and antioxidant status in patients with diabetic retinopathy
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Non Insulin Dependent Diabetes Mellitus is responsible for 60% cases of retinopathy in the population and is one of the common cause of blindness. Oxidative stress as measured by the levels of malondialdehyde, superoxide dismutase (SOD), glutathione peroxidase (GPx)

The development of diabetic retinopathy : effects of duration and control of diabetes
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RC Hardin, RL Jackson, TL Johnston, HG Kelly- Diabetes, 1956 Am Diabetes Assoc Evolution in the treatment of diabetes mellitus has been marked by a succession of problems brought to notice by newly acquired knowledge or by change in the course of the disease resulting from better therapy. For example, improved treatment has brought longer

Leukocyte adhesion molecules in diabetic retinopathy
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Diabetes is a systemic disease that causes a number of metabolic and physiologic abnormalities. One of the major microvascular complications of diabetes is diabetic retinopathy (DR), a leading cause of blindness in people over age 50. The mechanisms

The adrenal cortex and B-vitamins in diabetic retinopathy
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B Becker, GD Maengwyn-Davies, D Rosen- Diabetes, 1954 Am Diabetes Assoc The classic work of MacKenzie and Nettleship1 in 1877 first demonstrated capillary microaneurysms in the retina of a diabetic patient at autopsy. This important discovery was soon forgotten, and knowledge about diabetic retinopathy entered a dark age in which it was

Human genetics of diabetic retinopathy : current perspectives
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Diabetic retinopathy (DR) is a most severe microvascular complication which, if left unchecked, can be sight-threatening. With the global prevalence of diabetes being relentlessly projected to rise to 438 million subjects by 20 DR will undoubtedly pose a


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